Table 4 Group differentiated analysis of outcome parameters according to changes in the bone adjusted ratio of muscle volume.

From: Body composition impacts outcome of bronchoscopic lung volume reduction in patients with severe emphysema: a fully automated CT-based analysis

Parameter

Pre-implant (Baseline)

Follow-up (3-Month)

 

Follow-up (6-Month)

 

ΔMuscle, BAR %

 

 < -10

 ≤ 0

 > 0

> 10

 

 < -10

 ≤ 0

 > 0

 > 10

 

n

300

32

113

98

30

 

45

64

62

29

 
      

p

    

p

FEV1, L

.75

.75

.80*

.99*

.92*

 < 0.001

.68*

.84*

.89*

.96*

 < 0.001

RV, L

5.7

5.1*

4.8*

4.9*

4.4*

0.076

4.9*

4.6*

4.8*

4.3*

0.216

IVC, L

2.2

2.3

2.3*

2.7*

2.7*

0.293

2.2

2.4*

2.9*

2.7*

 < 0.001

6MWD, m

280

260

295*

350*

365*

 < 0.001

250*

277

400*

395*

 < 0.001

CAT score

27

24*

24*

22*

24*

0.473

28*

27

22*

22*

 < 0.001

ΔFEV1, L

 

.03

.12

.10

.26

 < 0.001

–.09

.06

.08

.31

 < 0.001

ΔFEV1, %

 

5.5

17.9

11.5

39.5

 < 0.001

–11

9

10.5

43

 < 0.001

ΔRV, L

 

–.8

–.82

–.8

–.85

0.509

–.75

–.8

–.9

–1

0.904

ΔRV, %

 

–15

–16

–13

–17

0.198

–15

–16

–16

–19

0.778

ΔIVC, L

 

.09

.35

.23

.55

 < 0.001

–.21

.23

.28

.62

 < 0.001

ΔIVC, %

 

4.3

16.6

10

28.4

 < 0.001

–8.7

7.9

11

28.8

 < 0.001

Δ6MWD, m

 

14

25

54

110

 < 0.001

–35

–5

78

140

 < 0.001

ΔCAT score

 

–2

–2

–2

–3.5

0.091

2

1

–4

–5.5

 < 0.001

  1. Significant values are in bolditalics, italics.
  2. 6MWD 6-min walking distance, CAT COPD assessment test, FEV1 forced expiratory volume in 1 s, IVC inspiratory vital capacity, RV residual volume, BAR bone adjusted ratio, IMAT intra- and intermuscular adipose tissue, EAT epicardial adipose tissue, PAT paracardial adipose tissue, SAT subcutaneous adipose tissue, TAT total adipose tissue. Values are displayed as median. Statistically significant differences between groups indicated with p-value and individual differences to baseline marked: *p < 0.001. We adjusted for multiple comparisons with Bonferroni correction.
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