Figure 2
From: The 3D in vitro Adrenoid cell model recapitulates the complexity of the adrenal gland
TEM analysis of cell ultrastructure of MTT and H295R grown as single cell type monolayers. (A) MTT cell grown in monolayer: the thin rim of cytosol poor of organelles and with few small chromaffin-like electron-dense granules indicates a poorly synthetic and active cell. Enlargement details the nucleus (N), mitochondria (M) and one putative catecholamine secretory granule (arrow). (B) H295R cell grown in monolayer: a magnification of cell showing the nucleus (N), mitochondria (M) and an electron-lucent vacuole resembling a liposome (arrow, REL), poor of organelles, indicating a rather steroidogenic immature stage. Scale bars are indicated at the right bottom.
