Figure 3
From: The 3D in vitro Adrenoid cell model recapitulates the complexity of the adrenal gland
TEM analysis of Adrenoid ultrastructure. Representative TEM images of Adrenoids at day 5: (a–c) H295R cells resemble metabolically active cells, rich in mitochondria in proximity to typical lipid droplets (asterisk) and profiles of smooth endoplasmic reticulum (SER, arrowheads), suggesting the occurrence of cholesterol biosynthesis. (d–f) MTT cells within the Adrenoid showing several granules with electron-dense core and electron-lucent halo, closely resembling the typical catecholamine-containing secretion granules (arrows). (g) The picture shows an MTT cell (left), recognizable because of the dense-cored granules, in close contact with an H295R cell (right), characterized by the presence of a large lipid droplet (asterisk). Scale bars are indicated at the right bottom. Nucleus (N), nucleolus, (Nu), mitochondria (M), smooth endoplasmic reticulum (SER) are indicated.
