Table 2 The biological effects of different indicators at various time points and dosage levels.

From: Evaluation of specific RBE in different cells of hippocampus under high-dose proton irradiation in rats

 

24 h after 20 Gy IR

24 h after 30 Gy IR

Proton

Photon

p

Proton

Photon

p

HE

CA1

33.64% ± 2.31%

26.25% ± 1.78%

0.009

41.81% ± 5.62%

32.69% ± 3.61%

0.118

CA2

44.31% ± 2.72%

34.35% ± 3.80%

0.173

55.12% ± 2.94%

40.54% ± 4.00%

0.048

CA3

52.69% ± 1.68%

42.04% ± 2.61%

0.001

59.35% ± 3.40%

44.16% ± 3.35%

0.029

CA4

48.75 ± 4.46%

35.30% ± 1.50%

0.003

65.37% ± 5.30%

56.96% ± 3.70%

0.536

DG

41.84% ± 4.41%

31.73% ± 1.34%

0.199

42.51% ± 5.11%

36.76% ± 3.50%

0.277

IHC

NeuN

0.629 ± 0.003

0.645 ± 0.004

0.027

0.602 ± 0.003

0.620 ± 0.008

0.049

Caspase-3

0.176 ± 0.006

0.161 ± 0.003

0.048

0.206 ± 0.006

0.195 ± 0.005

0.162

 

7 days after 20 Gy IR

7 days after 30 Gy IR

Proton

Photon

p

Proton

Photon

p

HE

CA1

20.01% ± 2.08%

20.06% ± 1.78%

0.984

28.71% ± 2.63%

31.37% ± 2.62%

0.867

CA2

37.43% ± 5.15%

34.61% ± 5.28%

0.976

49.16% ± 2.63%

52.45% ± 3.08%

0.821

CA3

39.71% ± 7.78%

38.62% ± 4.75%

0.999

50.29% ± 4.81%

53.00% ± 2.44%

0.949

CA4

47.10% ± 6.78%

43.37% ± 8.44%

0.982

47.10% ± 2.27%

46.37% ± 3.92%

0.998

DG

40.72% ± 7.91%

36.31% ± 5.71%

0.961

44.57% ± 2.78%

44.15% ± 3.94%

1.0

IHC

NeuN

0.625 ± 0.006

0.637 ± 0.004

0.069

0.618 ± 0.005

0.625 ± 0.003

0.602

Caspase-3

0.183 ± 0.003

0.188 ± 0.003

0.194

0.209 ± 0.003

0.219 ± 0.002

0.016