Table 1 The synthesis of (9R)-HHC and (9S)-HHC at different scales.

From: Hexahydrocannabinol (HHC) and Δ9-tetrahydrocannabinol (Δ9-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling

Entry

Synthesis scale (∆8-THC mass), g

Mass of 5% Pd/C per 1 g of ∆8-THC, mg

8-THC concentration, g/L

Duration of the reduction, days

9R:9S molar ratio

1

10

50

200

2

3:1

2

10

20

50

2

3:2

3

250

50

200

5

3:1

4

1000

50

250

14

3:1