Figure 3 | Scientific Reports

Figure 3

From: Selective impact of ALK and MELK inhibition on ERα stability and cell proliferation in cell lines representing distinct molecular phenotypes of breast cancer

Figure 3

Breast cancer subtype sensitivity to ALK and MELK inhibition. (a) Sensitivity values in the indicated cell lines representing different breast cancer (BC) subtypes for the reduction in ERα intracellular levels evaluated after treatment with esiRNA targeting MELK (a) or after administration of different doses of AP26113–AP (b) and (c) stratified based on progesterone receptor (PR) expression. Statistical significance is indicated by *(p < 0.05) calculated using the Student’s t-test test. Kaplan–Meier plots showing the relapse-free survival (RFS) probability in women with breast tumors expressing different levels of ERα, progesterone receptor (PR), and HER2 in relation to MELK mRNA levels (d–g) or ALK mRNA levels (h–k). The p-values for significant differences between RFS are provided in each panel. Data obtained from the website (https://kmplot.com/analysis/). All possible cutoff values between the lower and upper quartiles are automatically computed (i.e., auto-select the best cutoff on the website), and the best-performing threshold is used as a cutoff31.

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