Table 2 Patient’s characteristics pre-intervention and 3 weeks post-intervention.

From: Comparative impact of Roux-en-Y gastric bypass, sleeve gastrectomy or diet alone on beta-cell function in insulin-treated type 2 diabetes patients

 

Pre-intervention

3 Weeks post-intervention

PSMF

(n = 10)

RYGB

(n = 10)

SG

(n = 10)

PSMF

(n = 10)

RYGB

(n = 10)

SG

(n = 10)

Age (years)

60.6 ± 3.9

52.5 ± 7.9

52.9 ± 10.0

NA

NA

NA

Female (n (%))

8 (80)

5 (50)

4 (40)

NA

NA

NA

BMI (kg/m2)

38.7 ± 4.1*

41.3 ± 6.6

40.1 ± 7.9

37.0 ± 4.1

37.0 ± 5.7

36.8 ± 7.5

Weight (kg)

105.2 ± 17.0

118.8 ± 18.2

122.4 ± 28.4

100.5 ± 15.8

106.3 ± 15.2

112.2 ± 25.9

Weight loss (%)

NA

NA

NA

4.4 ± 1.8

10.4 ± 2.7

8.4 ± 2.7

Diabetes duration (years)

16.3 ± 8.3*

9.3 ± 7.8

13.5 ± 8.4

NA

NA

NA

HbA1c (%)

9.3 ± 1.6*

8.0 ± 1.8

8.7 ± 1.6

NA

NA

NA

HbA1c (mmol/mol)

78 ± 18

64 ± 20

72 ± 18

NA

NA

NA

Metformin (n (%))

9 (90)

8 (80)

10 (100)

7 (70)

7 (70)

10 (100)

Sulfonylurea (n (%))

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

GLP-1 agonist (n (%))

0 (0)

1 (10)

0 (0)

0 (0)

0 (0)

0 (0)

DPP-IV inhibitor (n (%))

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

Insulin bolus (IU)

49.4 ± 41.3

37.1 ± 19.1

52.9 ± 23.5

22.4 ± 18.4

14.2 ± 7.7

17.8 ± 15.8

Insulin basal (IU)

48.0 ± 19.9

42.1 ± 13.5

40.4 ± 19.1

45.5 ± 21.2

17.0 ± 4.1

29.1 ± 14.1

Fasting glucose (mg/dL)

115.2 ± 10.0

109.0 ± 9.3

116.1 ± 15.5

107.5 ± 14.9

106.3 ± 17.6

95.2 ± 11.5

Fasting C-peptide (pmol/L)

407.7 ± 145.7

648.2 ± 427.5

691.9 ± 347.0

501.7 ± 175.4

780.2 ± 333.6

760.6 ± 233.5

Fasting insulin (pmol/L)

317.6 ± 343.4

179.4 ± 174.3

217.6 ± 166.1

234.9 ± 179.1

117.3 ± 59.1

78.4 ± 43.0

  1. Pre-intervention values were compared using ANOVA (*p < 0.05) with Tukey adjustments for pairwise comparisons. Post-intervention values were compared to pre-intervention using a paired Student’s t-test (p < 0.05). Weight loss at 3 weeks post-intervention was compared using ANOVA (p < 0.05) with Tukey adjustments for pairwise comparisons (p < 0.001 RYGB vs. PSMF, p = 0.001 SG vs. PSMF, p = 0.13 RYGB vs. SG). Data are mean ± SD, unless otherwise stated. DPP-IV dipeptidylpeptidase IV, GLP-1 glucagon-like peptide 1, NA not applicable, PSMF protein-sparing modified fast, RYGB Roux-en-Y gastric bypass, SG sleeve gastrectomy.