Table 1 Optimization of the conditions for synthesis of benzo[c]acridin-8(9H)-one derivatives.
From: Efficient synthesis of benzoacridines and indenoquinolines catalyzed by acidic magnetic dendrimer
| |||||
|---|---|---|---|---|---|
Entry | Solvent | Catalyst(mg) | Condition | Time | Yield (%) |
1 | Solvent free | 20 | Reflux | 10Â h | 52 |
2 | EtOH | 20 | Reflux | 10Â h | 70 |
3 | H2O | 20 | Reflux | 10Â h | 60 |
4 | H2O | 20 | 50 °C | 10 h | 62 |
5 | H2O | 20 | 70 °C | 10 h | 65 |
6 | H2O/EtOH (1:1) | 20 | 50 °C | 6 h | 80 |
7 | H2O/EtOH (1:1) | 20 | Reflux | 6Â h | 75 |
8 | H2O/EtOH (1:1) | 20 | 70 °C | 6 h | 90 |
9 | H2O/EtOH (1:1) | 30 | 70 °C | 3 h | 95 |
10 | H2O/EtOH (1:1) | 50 | 70 °C | 3 h | 95 |
