Figure 1
Expression of cyclin F/CCNF in clear cell renal cell carcinoma compared to non-cancerous control tissue. Boxplot graphs of (a) cyclin F expression in tumor tissue (n = 108) and histologically normal tissue adjacent to the tumor (n = 37) of the institutional tissue macroarray (TMA) cohort based on immunohistochemistry (IHC); (b) cyclin F expression in tumor tissue (n = 172) and normal renal tissue (n = 16) of the commercially purchased microarray (TMA) cohort based on IHC; (c) CCNF expression levels in tumor tissue (n = 475) and normal renal tissue (n = 27) based on RNA-Seq data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases, respectively, downloaded from UCSC Xena Browser. Violin plots from the TNMplot web tool showing (d) CCNF expression levels in paired tumor tissue (n = 72) and adjacent normal tissue (n = 72) based on RNA-Seq data from the TCGA; (e) CCNF expression levels in paired tumor tissue (n = 210) and adjacent normal tissue (n = 210) based on the gene chip data derived from the Gene Expression Omnibus (GEO) database. (f) CCNF expression levels in primary tumor tissue (n = 556), non-paired normal tissue (n = 277), and metastasis (n = 58) based on the gene chip data derived from the GEO database.
