Table 1 Characteristics of study participants with and without intracranial artery stenosis (ICAS) (Japanese men, aged 40–79, SESSA).

From: Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis

Characteristics

Overall

ICAS (n, %)

p-value

N = 711

Without (506, 71.2)

With (205, 28.8)

Age, years

64.1 (58.4–71.1)

63.5 (57.3–69.3)

67 (60.2–73.6)

 < 0.001

Smoking status, n (%)

   

0.740

 Current

209 (29.4)

152 (30.0)

57 (27.8)

 

 Past

362 (50.9)

253 (50.0)

109 (53.2)

 

 Never

140 (19.7)

101 (20.0)

39 (19.0)

 

Drinking status, n (%)

   

0.032

 Current

563 (79.2)

413 (81.6)

150 (73.2)

 

 Past

37 (5.2)

25 (4.9)

12 (5.9)

 

 Never

111 (15.6)

68 (13.5)

43 (20.9)

 

BMI, kg/m2

23.6 ± 2.8

23.5 ± 2.8

23.9 ± 2.9

0.091

SBP, mmHg

135.5 ± 18.0

132.9 ± 17.5

142.2 ± 17.7

 < 0.001

DBP, mmHg

80.1 ± 10.8

79.7 ± 10.7

80.9 ± 11.1

0.173

Hypertension, n (%)

374 (52.6)

235 (46.4)

139 (67.8)

 < 0.001

HbA1c, %

5.4 (5.2–5.9)

5.4 (5.2–5.8)

5.5 (5.3–6.0)

0.001

Glucose, mg/dL

97 (91–107)

97.5 (91–106)

97 (91–111)

0.419

Diabetes mellitus, n (%)

155 (21.8)

99 (19.6)

56 (27.3)

0.023

Dyslipidemia, n (%)

397 (55.8)

261 (51.6)

136 (66.3)

 < 0.001

Total cholesterol, mg/dL

210.6 ± 32.5

209.3 ± 32.4

214.1 ± 32.7

0.076

Triglycerides, mg/dL

104 (76–150)

101 (76–47)

114 (78–57)

0.104

HDL-c, mg/dL

59.3 ± 17.1

61.3 ± 17.7

54.6 ± 14.2

 < 0.001

LDL-c, mg/dL

126.6 ± 30.8

123.7 ± 30.6

133.9 ± 30

 < 0.001

LDL-p, nmol/L

1299.7 ± 392.1

1255.4 ± 386.3

1408.8 ± 385.7

 < 0.001

IDL-p, nmol/L

99 (44–170)

99 (42–169)

97 (52–180)

0.477

Large LDL-p, nmol/L

628.3 ± 298.5

621.8 ± 294.9

644.3 ± 307.3

0.364

Small LDL-p, nmol/L

549.3 ± 419.2

513.1 ± 405.3

638.5 ± 440.1

 < 0.001

  1. ICAS was diagnosed by differentiation between the absence of detectable stenosis and the presence of stenosis.
  2. Values are presented as mean ± SD for continuous variables with approximately normally distribution or by median (Q1–Q3) with skewed distribution and n (%) for categorical variables. Differences in characteristics were evaluated by using the Student’s t-test, Wilcoxon rank sums test, or Chi squared test.
  3. SD, standard deviation; (Q1–Q3), interquartile range; BMI, body mass index; SBP, systolic blood pressure; HbA1c, glycated hemoglobin, DBP, Diastolic blood pressure; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; LDL-p, low-density lipoprotein particle; IDP, intermediate-density lipoprotein particle.
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