Figure 6 | Scientific Reports

Figure 6

From: Association of attenuated leptin signaling pathways with impaired cardiac function under prolonged high-altitude hypoxia

Figure 6

Hypoxia attenuates the expression of leptin signaling pathway proteins in rats myocardial tissues. (A) Western blot analysis of JAK2, p-JAK2, STAT3, p-STAT3, SOCS3, ERK1/2, p-ERK1/2, JNK, p-JNK, PI3K, p-PI3K, AKT, p-AKT, GSK3β, and p-GSK3β in left ventricular myocardial tissues. (B) Protein levels of p-JAK2, p-STAT3, and SOCS3 in left ventricular myocardial tissues. (C) Protein levels of PI3K, p-PI3K, Akt, in left ventricular myocardial tissues. (D) Protein levels of p-GSK3β in left ventricular myocardial tissues. (E) Protein levels of p-ERK1/2 and JNK. The protein expression normalized to β-Tubulin. n = 6. Data are presented as mean ± SEM. The p values are shown on the top of compared group by two-tailed unpaired t-test (for normally distributed data) or Mann–Whitney U test (for nonnormally distributed data).

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