Figure 1 | Scientific Reports

Figure 1

From: Reduction of hemagglutination induced by a SARS-CoV-2 spike protein fragment using an amyloid-binding benzothiazole amphiphile

Figure 1

A schematic illustration of a microplate assay to examine hemagglutination induced by soluble/suspended amyloids and inhibition of hemagglutination by amyloid-targeting small molecules. (A) red blood cells with no agglutination, (B) amyloid fibrils generated from spike protein-derived segments (here, denoted simply as “spike fibrils”) induce agglutination of red blood cells, (C) amyloid-binding molecules form bio-resistive coatings on the spike fibrils, resulting in inhibition of the interaction between red blood cells and spike fibrils. The rightmost column illustrates the visual evidence for no agglutination, hemagglutination and full/partial inhibition of agglutination in a microplate assay.

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