Figure 10
From: Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease
MSA derived conserved regions of Akt-like proteins in Trypanosoma and Leishmania species highlighted on full-length TcAkt (MSA: Figs. S22 and S23). Conserved residues are shown in red (in MSA residues are marked with an asterisk (*)), residues which have similar properties are colored in sand (in MSA residues marked with dots (:,.)), non-conserved residues are shown in grey. Residues involved in PIP interaction, are shown as sticks. (a) Conserved regions of Akt-like proteins among Trypanosoma spp. (Fig. S22) (b) Conserved residues in PIP binding site amongTrypanosoma spp. (c) Conserved regions of Akt-like proteins among Trypanosoma and Leishmania spp. (Fig. S23) (d) Conserved residues in PIP binding sites of Trypanosoma spp. and Leishmania spp. Further details are described in SI Section 3.
