Figure 11
From: Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease
Docking studies using human PIP3 competitor PIT-1 with HsAkt and TcAkt. Docking derived model of PIT-1 bound to (a) HsAkt-PH and (b) TcAkt-PH. 2D representation of interacting residues within 4 Å to PIT-1 of (c) HsAkt and (d) TcAkt. Basic charged residues enable interaction with PIT-1. In HsAkt residues K14, R23, and R86 are involved in ionic interactions with PIT-1. In TcAkt PIT-1 residues K11, K18 and K76 enable PIT-1 interaction.
