Figure 13
From: Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease
TcAkt inhibitors UBMC-4 and UBMC-6 binding sites mapped on the AF model of TcAkt. TcAkt PH domain is shown in turquoise, the flexible linker in grey, the TcAkt kinase domain in sand and the C-tail (including the h-motif) in lavender. P-sites are colored in red and shown as sticks. Ligand interacting residues of TcAkt are shown in green and presented as sticks. (a) UBMC-4 binding site determined by Bustamante et al.23 (b) UBMC-6 binding site determined by Ochoa et al.24.
