Figure 2
From: Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease
Surface representation of electrostatic potential and flexibility of TcAkt-PH. (a) Electrostatic surface of TcAkt-PH apo-form (PDB: 8OZZ) with zoomed details of nine basic amino acids: K11 (β1); R23 (β2); K15, K18, K19 (loop β1-β2); K36, R37, R38 (loop β3-β4); K76 (loop β6-β7). Coulombic electrostatic potential (kcal/(mol.ε) at 298 K) was calculated using ChimeraX60,61,62 (see Eq. 1). Negative electrostatic potential is shown in red (min: − 14.51), positive electrostatic potential in blue (max: 23.87). (b) Transparent surface with display of hetNOE values (see Eq. 3) of TcAkt-PH apo-form: low hetNOE values are colored in cyan, high hetNOE values in purple, not assigned (n.a.) residues in white. Orientation is consistent with Fig. 1b.
