Figure 7
From: Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease
ATP bound to TcAkt and HsAkt2 kinase domains. TcAkt kinase domain (dark grey) bound to ATP (orange sticks) was calculated with RoseTTAFold72. HsAkt2 kinase domain (light grey) was complexed with ATP analog, AMP-PnP (not shown) (PDB: 1O6K)73,74 (all-atom RMSD of aligned structures 0.883 Å). Zoomed details show ATP binding site. TcAkt residues are shown in dark sticks and HsAkt residues are shown in light sticks. Colors refer to specific regions of the kinase domain: Catalytic spine residues (turquoise), shell residues (red), DFG motif (blue), C-tail residues (yellow), G-loop (green), other residues interacting with ATP (grey).
