Table 3 Lipid mediators in plasma and synovial fluid.

From: The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty

 

Plasma

Synovial fluids

Pre

Day 1

Day 2

Day 14

Pre

Day 1

Day 2

Lipid mediators

 PGE2

  OA (n = 11)

1.5 ± 0.8

n.d

n.d

2.3 ± 1.2

4.1 ± 2.0

29 ± 14

225 ± 71

  P (vs pre)

 

0.188

0.188

0.938

 

0.186

0.020

  Non-OA (n = 9)

0.7 ± 0.7

n.d

1.0 ± 0.9

0.3 ± 0.3

35 ± 29

34 ± 16

68 ± 30

  P (vs pre)

 

0.644

0.964

0.644

 

0.999

0.656

 12-HETE

  OA (n = 11)

0.3 ± 0.1

0.4 ± 0.1

0.2 ± 0.0

0.4 ± 0.1

0.1 ± 0.1

20 ± 3

8.0 ± 1.1

  P (vs pre)

 

0.591

0.656

0.655

 

 < 0.001

 < 0.001

  Non-OA (n = 9)

0.2 ± 0.1

0.4 ± 0.2

0.2 ± 0.1

0.2 ± 0.1

0.6 ± 0.6

19 ± 3

7.7 ± 2.1

  P (vs pre)

 

0.395

0.935

0.995

 

 < 0.001

0.009

 15-HETE

  OA (n = 11)

0.01 ± 0.00

0.01 ± 0.00

0.01 ± 0.00

0.01 ± 0.00

0.01 ± 0.00

0.23 ± 0.04

0.19 ± 0.02

  P (vs pre)

 

0.791

0.779

0.990

 

 < 0.001

 < 0.001

  Non-OA (n = 9)

0.01 ± 0.00

0.01 ± 0.00

0.01 ± 0.00

0.01 ± 0.00

0.01 ± 0.01

0.22 ± 0.03

0.20 ± 0.04

  P (vs pre)

 

0.634

0.029

0.933

 

 < 0.001

 < 0.001

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