Figure 1
From: Malignant features of minipig melanomas prior to spontaneous regression
MeLiM early melanomas show all hallmarks of cancer. Longitudinal transcriptomic analysis and FSEA in GO terms of genes expressed in EP, P and PF groups and in DE genes between groups. Hypergeometric tests were used to determine the enrichment of expressed genes in each group (foreground set) among the total RNAseq gene set (background set corresponding to 16,559 genes). The CERNO method was used to analyze gene enrichment in ranked lists of p-values from DE analyses. Only GO terms assigned to cancer hallmarks, extracted from Chen et al. 6 were plotted and ranked by associated hallmarks (left). The total number of GO terms assigned to each cancer hallmark is shown in parentheses. The strength of the p-value is indicated by the transparency of color; the effect size (E or AUC) is indicated by the plot size. Significantly (p < 0.05) up-regulated genes in EP tumors are colored red while downregulated genes are colored blue; others are colored gray.
