Figure 6
From: Malignant features of minipig melanomas prior to spontaneous regression
Malignant characteristics of MeLiM melanoma cells in vivo. Analysis of xenograft growth of MeLiM melanoma cells into immunocompromised mice. Engraftment rate (a) and longitudinal development (b) of subcutaneous nodules reaching 250 mm3 at the site of injection of MeLiM melanoma cells at 1 million (blue) and 10 million (green) in NSG mice. For comparison, murine melanoma (B16, black) and porcine non-transformed melanocytic (PigMel, red) cell lines were injected. Engraftment rate (c) and nodule growth (d) of MeLiM melanoma cells from piglets aged 7–9 days (black circle) and 27–29 days (open circle) into nude mice. Growth of reimplanted MeLiM melanoma nodules in nude mice from lesions harvested from piglets aged 39–146 days (e, f). Melanoma cells could be transplanted up to 7 passages as shown for a piglet melanoma cells (g, h).
