Table 1 Clinical and histologic characteristics of melanoma progression in MeLiM pigs. Pig lesions were retrospectively classified in EP (early progression), P (progression) and PF (progression with signs of fibrosis) groups. Genotype at the CD4 locus may be Ref (reference sequence) or Alt (alternative sequence)19.
From: Malignant features of minipig melanomas prior to spontaneous regression
EP (n = 16) | P (n = 33) | PF (n = 21) | chi-square or ANOVA p-value | Tukey's post Test | |||
|---|---|---|---|---|---|---|---|
EP vs P | EP vs PF | P vs PF | |||||
Group description | |||||||
Pig's age (mean [min–max]) | 8.9 [3–12] | 20.9 [13–43] | 34.5 [19–49] | ||||
Presence of fibrosis = partial regression | No | No | Yes | ||||
Sex (M; F) | 7; 9 | 14; 19 | 9; 12 | 0.996 | |||
Tumor burden (Low; Medium; High) | 0; 6; 10 | 3; 12; 16 | 1; 9; 11 | 0.722 | |||
CD4 (Ref/Ref; Ref/Alt; Alt/Alt) | 2; 10; 4 | 12; 15; 6 | 7; 12; 2 | 0.385 | |||
Clinical observations of animals at sampling | |||||||
Palpable adenomegalies (%) | 6.3 | 24.2 | 76.2 | < 0.001 | |||
Clinical observations of lesions | |||||||
Lesion's size (mean in cm ± SD) | 2.13 ± 0.41 | 2.45 ± 0.67 | 3.04 ± 0.83 | < 0.001 | ns | *** | ** |
Lesion's size evolution (% variation/day ± SD) | 6.67 ± 7.06 | 4.17 ± 2.32 | 1.50 ± 1.77 | < 0.001 | ns | *** | * |
Lesion's size evolution | 0.019 | ||||||
Increasing (fast) (%) | 50.0 | 51.5 | 9.5 | ||||
Increasing (slow) (%) | 43.8 | 36.4 | 61.9 | ||||
Stable (%) | 6.3 | 12.1 | 28.6 | ||||
Description | 0.040 | ||||||
Plateau (%) | 6.3 | 30.3 | 19.0 | ||||
Dome (%) | 75.0 | 60.6 | 42.9 | ||||
Exophytic (%) | 18.8 | 9.1 | 38.1 | ||||
Ulceration | 0.083 | ||||||
No (%) | 0.0 | 30.3 | 19.0 | ||||
Yes (+) (%) | 31.3 | 24.2 | 42.9 | ||||
Yes (++) (%) | 68.8 | 45.5 | 38.1 | ||||
Histological observations of the tumoral zone | |||||||
Profile | 0.404 | ||||||
Dome or plateau (%) | 64.3 | 57.6 | 42.9 | ||||
Polypoid (%) | 35.7 | 42.4 | 57.1 | ||||
Clark's level | 0.989 | ||||||
IV (%) | 23.1 | 23.3 | 25.0 | ||||
V (%) | 76.9 | 76.7 | 75.0 | ||||
Ulceration | 0.727 | ||||||
No (%) | 15.4 | 16.1 | 9.5 | ||||
Low (%) | 46.2 | 32.3 | 28.6 | ||||
High (%) | 35.7 | 51.6 | 61.9 | ||||
High vascularization (%) | 78.6 | 93.5 | 90.5 | 0.314 | |||
Lymphoid infiltration | 0.074 | ||||||
No (%) | 50.0 | 53.1 | 42.9 | ||||
Yes (perilesional) (%) | 50.0 | 43.8 | 33.3 | ||||
Yes (perilesional & intralesional) (%) | 0.0 | 3.1 | 23.8 | ||||
Lesion's section size | |||||||
n | 7 | 19 | 17 | ||||
Length (mean in cm ± SD) | 1.42 ± 0.52 | 1.81 ± 0.77 | 2.10 ± 0.76 | 0.122 | |||
Depth (mean in cm ± SD) | 0.63 ± 0.20 | 0.73 ± 0.30 | 1.11 ± 0.33 | < 0.001 | ns | ** | ** |
Area (mean in mm2 ± SD) | 75.2 ± 53.8 | 110.2 ± 80.3 | 173.5 ± 91.2 | 0.017 | ns | * | ns |
