Figure 1
From: Dysregulated gene subnetworks in breast invasive carcinoma reveal novel tumor suppressor genes
Subnetwork for (a) Early stage ER/PR+/HER-2-. Seven dysregulated genes, coloured by the increasing mutation frequency (blue to red). NLGN3 and NRXN1 are frequently mutated while SYT13 is less mutated. The pathway analysis showed enrichment of TR/RXR activation pathway which activates PI3K pathway and regulates the biological process involved in cell survival and cell growth. (b) Early stage ER/PR-/HER-2+ containing six dysregulated genes. The NOTCH2 and NOTCH4 are highly mutated. The subnetwork may be involved in Notch signaling pathway, Th1 and Th2 activation pathway and epithelial-mesenchymal transition pathway. (c) Early stage TNBC. Contains eight dysregulated genes among which TTN is highly mutated which is followed by SYNE1. Netrin signaling, RhoA signaling, and axonal guidance signaling pathways may be affected. (d) Late stage TNBC. Contains fourteen dysregulated genes. DMD2 and ANK2 are significantly enriched in mutations. The subnetwork may regulate galactose degradation I pathway, colanic acid building blocks biosynthesis and nNOS signaling pathway.
