Table 5 Summary of each component of the subnetwork. The heat score value of each component is calculated based on the mutation frequency. The subnetwork is found to be involved in pathways e.g. Notch signaling pathway, Th1 and Th2 activation pathway and regulation of epithelial-mesenchymal transition pathway (EMT).
From: Dysregulated gene subnetworks in breast invasive carcinoma reveal novel tumor suppressor genes
Component | Heat score | Log2 Fold change | Expression (RNA-seq data analysis)* | Expression Atlas mRNA | Oncomine mRNA expression | Canonical pathways & p-value | |
|---|---|---|---|---|---|---|---|
MAML2 | 0.0108 | − 2.15 | Down | Down | Down | Notch signalling pathway, Th1 and Th2 activation pathway and regulation of epithelial-mesenchymal transition pathway | 2.88e−17, 1.00e−07 and 1.82E-05 |
DLL4 | 0.002 | − 1.02 | Down | Down | Down | ||
NOTCH4 | 0.0177 | − 1.98 | Down | Down | Down | ||
NOTCH2 | 0.0294 | − 1.49 | Down | Down | Down | ||
DTX1 | 0.0079 | − 1.77 | Down | Down | Down | ||
JAG1 | 0.0098 | − 1.21 | Down | Down | Down | ||
