Table 7 Summary of each component of the subnetwork in late stage TNBC. The table also represents status and mRNA expression of each component in expression atlas and Oncomine. The subnetwork appears to be involved in pathways as galactose degradation I, colanic acid building blocks biosynthesis and nNOS signaling pathway.
From: Dysregulated gene subnetworks in breast invasive carcinoma reveal novel tumor suppressor genes
Component | Heat score | Log2 Fold change | Expression (RNA-seq data analysis)* | Expression Atlas mRNA | Oncomine mRNA expression | Canonical pathways & p-value | |
|---|---|---|---|---|---|---|---|
CCDC18 | 0.0099 | 2.03 | Up | Up | Up | Galactose degradation I pathway, colanic acid building blocks biosynthesis and nNOS signaling pathway | 3.55e−03 9.91e−03 and 2.81E−02 |
CEP120 | 0.0089 | − 2.82 | Down | Down | Down | ||
NBPF3 | 0.003 | − 1.85 | Down | Up | Up | ||
AHNAK | 0.0277 | − 1.33 | Down | Down | Down | ||
NBPF1 | 0.0238 | − 2.89 | Down | Up | Down | ||
EHD2 | 0.0059 | − 1.51 | Down | Down | Down | ||
NFASC | 0.0149 | − 2.54 | Down | Down | Up | ||
CHL1 | 0.0069 | − 2.27 | Down | Down | Down | ||
TNS1 | 0.0109 | − 1.8 | Down | Down | Up | ||
L1CAM | 0.0248 | − 2.85 | Down | Down | Up | ||
GALK2 | 0.0059 | − 3.21 | Down | Down | Down | ||
DMD | 0.0465 | − 3.18 | Down | Down | Down | ||
ANK2 | 0.0307 | − 2.2 | Down | Down | Down | ||
ANK1 | 0.0257 | − 5.74 | Down | Up | Down | ||
