Table 8 Mutational detail of the components of subnetwork showing total mutations (unique) across the four studies, TCGA; Cell 2015, TCGA; Nature 2012, TCGA; PanCancer Atlas and TCGA; Provisional using cbioportal. The cluster harbored several types of mutations as missense, fusion, splice, frame-shift, in-frame. The somatic mutation frequency of NLGN3 and NRXN1 was found to 1.0%.
From: Dysregulated gene subnetworks in breast invasive carcinoma reveal novel tumor suppressor genes
Gene name | Total mutations | Mutation type | Mutation showing deleterious impact | Somatic mutation frequency (%) |
|---|---|---|---|---|
SYT2 | 10 | Missense, Fusion | 6 | 0.6 |
SYT9 | 8 | Missense, Fusion | 6 | 0.3 |
SYT6 | 8 | Missense, Splice, Frame_shift_deletion | 3 | 0.4 |
NLGN1 | 9 | Missense, Fusion, Nonsense | 6 | 0.5 |
NLGN3 | 16 | Missense, Splice, Frame_shift_deletion, Frame_shift_insertion | 10 | 1 |
SYT13 | 1 | Missense | 0 | 0.1 |
NRXN1 | 22 | Missense, Fusion, Frame_shift_deletion, Frame_shift_insertion | 7 | 1 |
BRCA1 | 42 | Missense, Splice, Nonsense, Frame_shift_deletion, Frame_shift_insertion, In_frame_deletion | 10 | 1.7 |
BRCA2 | 50 | Missense, Splice, Nonsense, Fusion, Frame_shift_deletion, Frame_shift_insertion, In_frame_deletion | 11 | 1.9 |
