Table 9 Mutational detail of the NOTCH gene and interactors representing total unique mutations across the four studies, TCGA; Cell 2015, TCGA; Nature 2012, TCGA; PanCancer Atlas and TCGA; Provisional. The components harbored several types of mutations as missense, fusion, splice, frame-shift, in-frame as shown in the table.
From: Dysregulated gene subnetworks in breast invasive carcinoma reveal novel tumor suppressor genes
Gene name | Total mutations | Mutation type | Mutation showing deleterious impact | Somatic mutation frequency (%) |
|---|---|---|---|---|
MAML2 | 12 | Missense, Fusion, Frame_shift_deletion, Frame_shift_insertion | 4 | 0.6 |
DLL4 | 3 | Missense | 2 | 0.2 |
NOTCH4 | 21 | Missense, Frame_shift_deletion, In_frame_deletion, In_frame_insertion | 5 | 0.9 |
NOTCH2 | 46 | Missense, Fusion, Non-sense, Frame_shift_deletion, Frame_shift_insertion | 13 | 2.2 |
DTX1 | 7 | Missense, Fusion, Nonsense | 3 | 0.4 |
JAG1 | 14 | Missense, Splice, Nonsense, Frame_shift_deletion | 4 | 0.7 |
