Table 1 The principal findings of this investigation.
From: Macrophage-derived CD36 + exosome subpopulations as novel biomarkers of Candida albicans infection
Parameter | MPO in C. albicans immune evasion | CD36 as biomarker for C. albicans |
|---|---|---|
Function/role | Myeloperoxidase (MPO) expression in macrophage-derived exosomes during C. albicanss infection | CD36 expression as a pattern recognition receptor in macrophage-derived exosomal subpopulations |
Key observations | Enhanced MPO expression in exosomes from C. albicans-infected macrophages < br >—Association with NETosis and METs formation < br >—Contribution to immune evasion by C. albicans | Differential CD36 expression in response to C. albicans < br >—Potential role in cellular pyroptosis and immune response modulation |
Findings | Significantly increased MPO in infected versus uninfected macrophages. < br > Elevated METs release under PMA and C. albicans stimulation | Notably higher CD36 levels in exosomal subpopulations during C. albicans infection |
Clinical Implications | MPO as a novel target for elucidating C. albicans immune evasion strategies | CD36 subpopulations as promising early biomarkers for C. albicans infection; potential therapeutic targets in fungal infections |
