Figure 2
From: Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6
Single-cell RNA expression of the SOX6-LIN28B/Let-7 axis in human fetal hematopoiesis. (a) Normalized expression of SOX6, LIN28B, as well as the downstream genes MYC, and IGF2BP1 in human yolk sac cells shown as UMAP. (b) 15 UMAP clusters are associated with cell types according to the expression of distinct marker genes from Popescu et al.42. Dataset contains 10,071 yolk sac cells derived from 3 individuals at the age of 4–6 PCW. (c) Normalized expression of SOX6, LIN28B, as well as the downstream genes MYC, and IGF2BP1 in human fetal liver cells shown as UMAP (Uniform Manifold Approximation and Projection) plots. (d) 27 UMAP clusters are associated with cell types according to the expression of distinct marker genes. Dataset contains 113,063 fetal liver cells derived from 16 individuals at the age of 7–17 PCW. PCW, post conception week; MEMP, megakaryocyte-erythroid progenitors; DC, dendritic cells; HSC-MPP, hematopoietic stem cells and multipotent progenitors; ILS, induced leucocyte stem; Erythroid EZ, early (HGE expressing) erythroid; Erythoid M, mid erythroid; Erythroid AB, late (HGA and HGB expressing) erythroid.
