Figure 6
From: Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6
Proposed model of LIN28B repression by SOX6. In fetal cells and in cancers with illegitimate LIN28B reactivation, LIN28B blocks the processing of Let-7 precursors to Let-7 miRNA. Let-7 reduction leads to the failure of silencing of proproliferative genes, including c-MYC and IGF2BP1, thus promoting cell proliferation. SOX6, by repressing LIN28B transcription, allows the maturation of Let-7 miRNAs, among the most abundant miRNAs in adult cells17. Let-7 miRNAs post-transcriptionally repress proproliferative genes inducing growth arrest (created with Biorender).
