Figure 2 | Scientific Reports

Figure 2

From: St. John's wort extract Ze 117 alters the membrane fluidity of C6 glioma cells by influencing cellular cholesterol metabolism

Figure 2

Effect of single Ze 117 ingredients on the total cholesterol content of C6 cells. (A) Relative fold change in total cholesterol content in C6 cells after 48 h of preincubation with Ze 117 (25.0 µg/ml), simvastatin (1.0 µM) or dexamethasone (1.0 µM) compared to untreated control (UTC) cells. (B) Relative fold change in total cholesterol content in C6 cells after 48 h of preincubation with hypericin (hr; 0.01 and 0.1 µM), hyperforin (hf; 0.1 and 1.0 µM), biapigenin (bi; 1.0 and 1.5 µM) or quercetin (qu; 1.0 and 1.5 µM) compared to the untreated control. The results are displayed as the mean and SEM of at least three individual experiments. Values marked * were considered significantly different (unpaired t test with Welch’s correction) compared to the untreated control (UTC) with p ≤ 0.05.

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