Figure 4
From: Lactobacillus paracasei subsp. paracasei 2004 improves health and lifespan in Caenorhabditis elegans
Longevity increase induced by L. paracasei subsp. paracasei 2004 feeding requires the transcription factor DAF-16. (A) Box plot shows the relative mRNA levels of daf-16 h (left), skn-1 (middle), and daf-16 (right) in animals fed the indicated bacterium. L. paracasei subsp. paracasei 2004 feeding upregulated the expression of daf-16 mRNA. P-values were calculated by an unpaired t-test. *, p < 0.05. (B) Survival curves of the wild-type N2 (left) and two mutants, EU31[skn-1(zu135)] and CF1038[daf-16(mu86)], fed the indicated bacterium. L. paracasei subsp. paracasei 2004 feeding extended the C. elegans lifespan in a DAF-16-dependent manner. P-values were calculated by a log-rank test with Bonferroni correction. **, p < 0.01. See Table S8 for detailed statistics.
