Figure 3
Naloxone-induced social behavioural deficits in chronic but not acute morphine-administered mice. (A,B) Schematic representation of experimental timelines of social preference test for acute (i.p.) and chronic (i.p.) morphine-treated mice, respectively. (C,D) No preference for the social-paired compartment in acute (C) or chronic (D) morphine treated mice 30 min after naloxone injection during the habituation phase of the social preference test. (E,F) Acute morphine induced (E) no difference in social preference compared to saline whereas chronic morphine (F) decreased preference for the social compartment when compared to saline 30 min after naloxone injection. Data are represented as mean ± SEM. Dots represent individual values. *p < 0.05. N = 10–15/group.
