Figure 4
Naloxone-induced anxiety-like behaviour in acute and chronic morphine-administered mice. (A,B) Schematic representation of experimental timelines of open field test for acute (i.p.) and chronic (i.p.) morphine-treated mice, respectively. (C,F) Decreased time in centre zone in the open field test during naloxone-precipitated withdrawal from acute and chronic morphine, respectively. (D,E) No effect of precipitated withdrawal from acute morphine on entries to centre and distance travelled in the open field test, respectively. (G,H) Decreased entries to centre zone and distance travelled in the open field test during naloxone-precipitated withdrawal from chronic morphine. Data are represented as mean ± SEM. Dots represent individual values. *p < 0.05, **p < 0.01. N = 10–15/group.
