Table 1 Demographic and clinical characteristics of the participants.
Characteristics | All | CU A+ | Prodromal AD | p-value* |
|---|---|---|---|---|
Number of subjects | 180 | 45 | 135 | |
Age (SD), years | 76.82 (5.37) | 76.56 (5.36) | 76.91 (5.39) | 0.702 |
Sex | 1.000 | |||
Female, n (%) | 108 (60%) | 27 (60%) | 81 (60%) | |
Male, n (%) | 72 (40%) | 18 (40%) | 54 (40%) | |
Education (SD), y | 12.24 (4.65) | 12.51 (4.79) | 12.16 (4.61) | 0.658 |
APOE ε4 carrier | 0.070 | |||
APOE ε4−, n (%) | 83 (46.1%) | 26 (57.8%) | 57 (42.2%) | |
APOE ε4+, n (%) | 97 (53.9%) | 19 (42.2%) | 78 (57.8%) | |
Verbal fluency (SD)a | 12.90 (4.52) | 16.22 (4.92) | 11.72 (3.74) | 0.038 |
Boston naming test (SD)a | 10.80 (2.60) | 11.93 (2.05) | 10.40 (2.66) | 0.108 |
MMSE (SD) | 24.31 (3.75) | 26.38 (2.77) | 23.61 (3.78) | 0.086 |
Construction praxis test (SD)a | 9.86 (1.48) | 10.18 (1.01) | 9.75 (1.60) | 0.043 |
Word list memory (SD)a | 13.66 (4.22) | 17.62 (3.80) | 12.25 (3.40) | 0.596 |
Word list recall (SD)a | 2.49 (2.49) | 5.22 (2.04) | 1.53 (1.84) | 0.194 |
Word list recognition (SD)a | 6.71 (2.82) | 9.20 (1.22) | 5.83 (2.70) | < 0.001 |
Construction recall test (SD)a | 3.67 (3.18) | 6.60 (2.62) | 2.63 (2.67) | 0.671 |
Trail making test A (SD)a | 71.37 (48.00) | 58.22 (33.06) | 76.03 (51.89) | 0.055 |
Trail making test B (SD)b | 227.9 (102.38) | 181.48 (100.37) | 244.66 (98.22) | 0.555 |
Digit span forward (SD)c | 5.73 (1.27) | 5.93 (1.20) | 5.65 (1.30) | 0.644 |
Digit span backward (SD)c | 0.44 (1.19) | 0.56 (0.99) | 0.39 (1.26) | 0.159 |
Frontal assessment battery (SD)c | 14.36 (2.57) | 15.22 (2.22) | 14.05 (2.63) | 0.578 |
Global SUVR (SD, range) | 1.41 (0.23, 0.98–2.18) | 1.37 (0.22, 1.02–1.89) | 1.42 (0.23, 0.98–2.18) | 0.231 |
Total GMV/ICV (SD) | 0.35 (0.02) | 0.36 (0.03) | 0.35 (0.02) | 0.006 |
