Figure 4
From: Social interactions and olfactory cues are required for contagious itch in mice
Olfactory inputs regulate enhanced contagious itch by past and current experiences of itch. (A) The primed anosmic mice exhibited a significant reduction in look-scratch behavior, an effect potentiated in non-anosmic primed mice (**** P < 0.0001 pairwise comparisons). The number of looks (B) and total scratching bouts (C) are comparable between the groups. Itch priming was induced by the injection of 100 µg/site of C48/80 one day before the designated experimental day. (D) Anosmic mice with concurrent experience of itch induced by the sub-effective dose of C48/80 exhibited significantly lower counts of look-scratch responses but a comparable number of (E) looks and (F) total scratching bouts compared to their non-anosmic counterparts. Values are presented as mean ± SEM.
