Figure 2
From: Trimebutine prevents corneal inflammation in a rat alkali burn model
HMGB1 staining and RAGE staining. In the normal cornea, HMGB1 and RAGE are expressed in the epithelium (a, f). Bar, 50 μm. Alkaline injury resulted in a broader distribution of HMGB1 and RAGE in the corneal stromal layer than in uninjured normal corneas, suggesting infiltration of inflammatory cells expressing these molecules in the corneal stroma (b, c, g, h). Trimebutine reduced the number of positively stained cells for HMGB1 and RAGE in the corneal stroma (d, e, i, j). Compared with the vehicle group, especially on day 4, trimebutine effectively decreased the number of HMGB1 and RAGE positive cells (k, l). Data are presented as the mean ± standard deviation (n = 8 samples/group) *P < 0.05, **P < 0.01. HMGB1, high mobility group box 1; RAGE, receptor for advanced glycation end products.
