Figure 3
From: Trimebutine prevents corneal inflammation in a rat alkali burn model
MPO staining. To investigate the infiltrating neutrophils, myeloperoxidase (MPO) staining was performed (a–d). Bar, 50 μm. The trimebutine ophthalmic solution significantly decreased the degree of infiltrating neutrophils compared with vehicle by day 7 (i). Data are presented as the mean ± standard deviation (n = 8 samples/group). *P < 0.05. ED-1 staining. To investigate the infiltrating macrophages, CD68 antibody (ED-1) staining was performed (e–h). Bar, 50 μm. Trimebutine treatment significantly suppressed ED-1-positive macrophages on days 1 and 4 compared with vehicle treatment (j). Data are presented as the mean ± standard deviation (n = 8 samples/group) *P < 0.05.
