Figure 6
From: Trimebutine prevents corneal inflammation in a rat alkali burn model
Expression of proinflammatory cytokine mRNAs in the cornea before alkaline injury and 4 and 7 days after. The mRNA expression levels of tumor necrosis factor (TNF)-α (a), interleukin (IL)-6 (b), IL-1β (c), and chemokine (C–C motif) ligand 2 (CCL2) (d) were measured. The level of each cytokine peaked on day 4 as did HMGB1- and RAGE-positive cells. IL-6, IL-1b, and CCL2 levels decreased on day 7. Only IL-1β levels decreased with trimebutine treatment (a–d). Data are expressed as the mean ± standard error (n = 8 samples/group). **P < 0.01. HMGB1, high mobility group box 1; RAGE, receptor for advanced glycation end products.
