Table 1 Anti-DENV2 efficacy of pimecrolimus, ascomycin, and tacrolimus.

From: Antiviral activity of pimecrolimus against dengue virus type 2 infection in vitro and in vivo

Compounds

Vero

BHK-21

CC50a

IC50b

CC50a

IC50b

Pimecrolimus

 > 20

3.4 ± 0.1

 > 20

3.2 ± 0.1

Ascomycin

 > 20

16.5 ± 0.1

 > 20

14.6 ± 0.7

Tacrolimus

 > 20

14 ± 0.2

 > 20

11.6 ± 0.3

Ribavirin

 > 500

122.8 ± 6.6

 > 500

68.4 ± 3.8

  1. aConcentration required to reduce cell growth by 50% (ÎĽM).
  2. bConcentration required to inhibit virus-induced cytopathic effect by 50% (ÎĽM).
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