Figure 1 | Scientific Reports

Figure 1

From: Identification of master regulator genes controlling pathogenic CD4+ T cell fate in inflammatory bowel disease through transcriptional network analysis

Figure 1

Bulk RNAseq analysis of splenic and colonic CD4+ T cells from colitis and control mice. (A) Illustration of the experimental strategy conducted to determine the differential gene expression and to built the master regulator network. (B) Quantification of body weight loss in experimental mice. Mean ∓ SEM are indicated. *, p < 0.05 by Student's t-test. (C) Principal Component Analysis (PCA) of RNAseq-based expression data from splenic and colonic samples from mice undergoing colitis or from healthy controls. (D) Quantification of differentially expressed genes (DEGs) found in splenic and colonic CD4+ T cells from mice undergoing colitis respect to the control conditions (n = 4). DEG upregulated are represented in red, whereas DEG downregulated are represented in blue.

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