Figure 7 | Scientific Reports

Figure 7

From: Amperometry approach curve profiling to understand the regulatory mechanisms governing the concentration of intestinal extracellular serotonin

Figure 7

Amperometry approach curve profiling to unravel the properties of the SERT and autoreceptors. Current approach curve profiles were obtained at various concentrations of fluoxetine. (A) Release of 5-HT ([5-HT]r), (B) reuptake of 5-HT and (C) extracellular concentration of 5-HT ([5-HT]e) in the ileum. (D) Release of 5-HT ([5-HT]r), (E) reuptake of 5-HT and (F) extracellular concentration of 5-HT ([5-HT]e) in the colon. (n = 6) The dotted orange line indicates the concentration of fluoxetine that causes a 50% reduction in 5-HT release. The dotted purple line indicated the IC50 for fluoxetine at the SERT.

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