Figure 1 | Scientific Reports

Figure 1

From: Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis

Figure 1

Pharmacological profile of PIPE-791. (A) Binding kinetics of PIPE-791 in recombinant membranes. Three concentrations of 3H-PIPE-791 (0.25, 0.5 and 1 nM) were incubated with 1 µM PIPE-791 then added to membranes at different time points, resulting in a calculated t1/2 of 519 min (graphs are mean ± SD, n = 4). (B,C) Saturation binding was performed using increasing concentrations of [3H]-PIPE-791 in mouse or human brain homogenate (mean ± SD, n = 4).

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