Table 4 Spearman correlation between ELABELA and Apelin and study variables in all subjects.

From: Decreased plasma ELABELA level as a novel screening indicator for heart failure: a cohort and observational study

Parameters

Plasma ELABELA, ng/ml

Plasma Apelin, pg/ml

r value

P value

r value

P value

Age, years

0.427

0.574

0.340

0.436

Sex

0.081

0.138

0.024

0.666

Body mass index, kg/m2

0.254

0.082

0.184

0.079

Coronary artery disease

0.004

0.949

0.175

0.001**

Diabetes mellitus

 − 0.098

0.072

 − 0.020

0.717

Chronic renal failure

0.052

0.264

0.044

0.687

Hypertension

0.083

0.130

 − 0.030

0.581

Systolic blood pressure, mmHg

0.038

0.488

 − 0.076

0.166

Diastolic blood pressure, mmHg

0.164

0.003**

 − 0.107

0.050

Mean arterial pressure, mmHg

0.117

0.033*

 − 0.099

0.069

Heart rate, bpm

 − 0.081

0.139

0.145

0.008**

Plasma BNP, pg/ml

 − 0.704

 < 0.001***

0.336

 < 0.001***

Plasma creatine, μmol/l

 − 0.235

 < 0.001***

0.034

0.539

Plasma urea nitrogen, μmol/l

 − 0.284

 < 0.001***

0.138

0.011*

Plasma uric acid, μmol/l

 − 0.110

0.045*

 − 0.012

0.821

Plasma LDL-c, mmol/l

0.134

0.014*

 − 0.094

0.087

Plasma HDL-c, mmol/l

0.126

0.021*

 − 0.017

0.759

Plasma total cholesterol, mmol/l

0.207

 < 0.001***

 − 0.080

0.145

Plasma triglyceride, mmol/l

0.164

0.003**

 − 0.087

0.113

Plasma ELABELA, ng/ml

–

–

 − 0.229

 < 0.001***

Plasma Apelin, pg/ml

 − 0.229

 < 0.001***

–

–

LVEF, %

0.183

0.001**

 − 0.144

0.037*

LAD, mm

 − 0.265

 < 0.001***

0.295

 < 0.001***

LVEDd, mm

 − 0.231

 < 0.001***

0.213

 < 0.001***

LVEDs, mm

 − 0.223

 < 0.001***

0.187

0.001**

IVST, mm

 − 0.102

0.061

0.135

0.013*

LVPW, mm

 − 0.167

0.002**

0.108

0.048*

RVIDd, mm

 − 0.045

0.416

0.068

0.218

NYHA function grade

 − 0.700

 < 0.001***

0.365

 < 0.001***

  1. BNP, B-type natriuretic peptide; LDL-c, low-density lipoprotein cholesterol; HDL-c, high-density lipoprotein cholesterol; LAD, left atrial diameter; LVEDd, left ventricular end-diastolic diameter; LVEDs, left ventricular end-systolic diameter; LVEF, left ventricular ejection fraction; IVST, interventricular septum thickness; LVPW, left ventricular posterior wall thickness; RVIDd, right ventricular internal dimension diameter. HF, heart failure. *P < 0.05; **P < 0.01; ***P < 0.001.
  2. Significant values are in bold.