Figure 1 | Scientific Reports

Figure 1

From: Inducible deletion of microRNA activity in kidney mesenchymal cells exacerbates renal fibrosis

Figure 1

PDGFR-β expression in Pdgfr-β-CreERT2;tdTomato mice administered tamoxifen is well-localized in renal mesenchymal cells and exacerbated after UUO. (A) Schematic of Pdgfr-β-CreERT2 and Rosa26tdTomato mice. (B) Renal mesenchymal cells stained green with anti-PDGFR-β in the contralateral kidney (CLK) and UUO kidney. PDGFR-β shows colocalization of the tdTomato reporter in red. CreERT2 is absent in control mice. Scale bar = 50 µm. (C) Graph illustrating the proportion of tdTomato-positive mesenchymal cells expressing PDGFR-β (%PDGFR-β/tdTomato). tdTomato is effectively and specifically expressed in PDGFR-β-positive fibroblasts (n = 3).

Back to article page