Figure 4
From: In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase
PK profile of CocH5-Fc(M6) in rats (n = 3 per group) received i.v. administration of 0.075, 1.5, 3 or 10 mg/kg CocH5-Fc(M6). (A) Time-dependent plasma concentrations of CocH5-Fc(M6). (B) Dose dependence of AUC0-∞, showing the linearity of the PK profile. (C) Dose dependence of Cmax, showing the linearity of the PK profile. The data are shown as Mean ± SEM.
