Table 1 Pharmacokinetic parameters of CocH5-Fc(6M) by the non-compartmental analysis.

From: In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase

Dose (mg/kg, i.v.)

0.075

1.5

3

10

Cmax (mg L−1)a

2.17 ± 0.09

38.92 ± 1.64

70.17 ± 5.10

198.02 ± 15.41

t1/2 (day)

9.11 ± 0.31

8.75 ± 0.82

9.38 ± 0.41

9.26 ± 0.47

CL (mL × day−1 kg−1)b

8.65 ± 0.70

11.29 ± 1.15

12.7 ± 1.67

14.8 ± 0.67

Vz (mL/kg)c

113.81 ± 9.05

139.91 ± 0.27

171.04 ± 17.80

198.09 ± 13.76

Vss (mL/kg)d

108.72 ± 8.97

132.82 ± 2.11

160.15 ± 16.30

186.72 ± 11.64

MRT0-t (day)e

8.95 ± 0.16

8.93 ± 0.48

9.12 ± 0.23

9.29 ± 0.28

MRT0-∞ (day)f

12.58 ± 0.55

12.02 ± 1.27

12.68 ± 0.52

12.60 ± 0.56

AUC0-24 (mg × day L−1)

1.11 ± 0.07

16.55 ± 0.36

28.99 ± 2.95

75.28 ± 3.47

AUC0-t (mg × day L−1)

7.91 ± 0.69

122.56 ± 15.07

218..76 ± 29.55

612.01 ± 26.93

AUC0-∞ (mg × day L−1)

8.85 ± 0.74

135.37 ± 12.52

244.44 ± 34.60

677.69 ± 28.94

  1. aCmax—Maximum observed concentration.
  2. bCL—Clearance.
  3. cVZ—Volume of distribution based on the terminal phase.
  4. dVSS—An estimate of the volume of distribution at steady-state based on the last observed non-steady-state data.
  5. eMRT0-t—Mean residence time from the time of dosing to the time of the last measurable concentration.
  6. fMRT0-∞—Mean residence time from the time of dosing to the infinite.
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