Figure 2 | Scientific Reports

Figure 2

From: Immune profiling of dedifferentiated liposarcoma and identification of novel antigens for targeted immunotherapy

Figure 2

Active molecular pathways and cell types within DDLS reveal tumor heterogeneity. (A) Overview of pathway scores in DDLS compared to healthy adipose tissue. Significance calculated using 2way ANOVA Sidak’s multiple comparisons test. * = p-value < 0.05, ** = p-value < 0.01 (B) Bar graphs showing log2 fold change in expression of individual genes within the adhesion pathway. Significance calculated using the Benjamini-Yekutieli procedure. * = p-value < 0.05, ** = p-value < 0.01, *** = p-value < 0.001, **** = p-value < 0.0001 (C) log2 mRNA counts of ALCAM in healthy adipose tissue, primary tumors of patients with metastasis, and those without metastasis. Significance calculated using One way Anova, * = p-value < 0.05, ** = p-value < 0.01 (D) Cell type scores of different immune cells detected in DDLS.

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