Table 2 Cytokines and chemokines expression in overweight volunteers after 180 days of supplementation.

From: Nutraceutical blends predict enhanced health via microbiota reshaping improving cytokines and life quality: a Brazilian double-blind randomized trial

Group

NSupple

NSupple_Silybum

T0

T180

p

T0

T180

p

(pg/mL)

Mean ± SD

Min–Max

Mean ± SD

Min–Max

Mean ± SD

Min–Max

Mean ± SD

Min–Max

IL-1β

2.48 ± 0.72

1.01–5.69

1.88 ± 0.53

0.01–4.28

-

2.42 ± 1.05

1.40–3.65

2.24 ± 0.63

1.26–2.67

-

IL-4

4.72 ± 1.02

0.01–14.01

6.06 ± 1.26

0.01–18.42

0.017

5.71 ± 1.44

0.01 -14.72

7.47 ± 2.37

1.16–26.79

0.032

IL-6

1.17 ± 0.13

1.01–1.47

1.36 ± 0.31

1.01–2.14

0.022

1.39 ± 0.18

1.14–1.55

1.14 ± 0.12

1.01–1.32

0.016

IL-10

2.72 ± 0.16

1.33–4.19

2.81 ± 0.20

2.04–5.16

-

2.54 ± 0.95

1.52–5.12

2.35 ± 0.38

1.61–2.91

-

IL-12p70

6.80 ± 0.52

2.93–13.51

8.72 ± 0.58

3.39–13.58

0.002

8.63 ± 3.19

4.98–17.32

8.87 ± 2.45

4.44–14.60

-

TNF-α

1.85 ± 0.28

1.32–2.42

1.85 ± 0.22

1.56–2.30

-

2.49 ± 1.12

1.80–5.92

2.10 ± 0.99

1.27–5.15

0.001

IFN-γ

3.44 ± 1.32

1.11–8.54

1.53 ± 0.72

0.01–4.62

0.031

7.88 ± 3.27

1.31–27.58

4.63 ± 2.31

0.01–14.95

0.027

CXCL10/IP-10

4.68 ± 0.68

1.85–12.30

7.09 ± 1.61

2.28–30.85

0.030

4.02 ± 1.66

1.95–6.73

4.18 ± 0.96

2.71 ± 5.74

-

CCL5/RANTES

42.62 ± 6.33

8.58–97.52

29.84 ± 4.51

0.01–69.29

0.050

36.5 ± 6.92

10.02–79.19

23.36 ± 2.39

12.43–36.04

0.029

CXCL9/MIG

133.2 ± 27.03

20.20–307.4

87.75 ± 15.25

26.79–197.1

0.037

136.5 ± 87.52

10.34–296.3

91.22 ± 60.66

18.79–206.3

0.047

CXCL8/IL-8

67.74 ± 8.85

18.14 -166.3

70.89 ± 7.55

27.54–156.7

-

65.28 ± 26.92

21.16–122.7

71.37 ± 24.66

24.48–106.5

-

IL-6/IL-10 ratio

0.45 ± 0.15

0.22–0.87

0.34 ± 0.21

0.01–0.60

0.028

0.58 ± 0.15

0.40–0.80

0.45 ± 0.12

0.27–0.61

0.006

TNF-α/IL-10 ratio

0.68 ± 0.05

0.51–0.97

0.82 ± 0.10

0.11–1.35

-

0.93 ± 0.38

0.46–1.75

0.77 ± 0.18

0.43–1.15

-

  1. Values are expressed as pg/mL (mean ± standard deviation) in NSupple (n = 6–21) and NSupple_Silybum (n = 6–20).
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