Figure 2 | Scientific Reports

Figure 2

From: Dihydroartemisinin-driven selective anti-lung cancer proliferation by binding to EGFR and inhibition of NRAS signaling pathway-induced DNA damage

Figure 2

The expression of NRAS and p-ERK in Malignant lung cancer cells was higher than in normal lung cells. 16HBE, LLC and A549 were cultured for 24 h. (A–D) The normalized gene expression of NRAS, Cdc25a, CDK4 and γ-H2A.X in lung cancer tissues and normal tissues was analyzed and presented (*p < 0.05). The TNMplot database was utilized. (E) The expression of NRAS and p-ERK1/2 was analyzed through WB. (F) The DNA damage-associated molecules γ-H2A.X and proliferation-associated molecules Cdc25a were detected by WB. (G) The NRAS, p-ERK1/2, Cdc25A, and γ-H2A.X expression in tumor grafts and lung tissue was measured by IHC.

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