Figure 6 | Scientific Reports

Figure 6

From: Dihydroartemisinin-driven selective anti-lung cancer proliferation by binding to EGFR and inhibition of NRAS signaling pathway-induced DNA damage

Figure 6

DHA could bind to EGFR and drive the suppressive function. (A) Venn diagram showing the overlap of DHA and Non-small cell lung cancer (NSCLC). (B) The protein interaction network diagram was constructed, wherein EGFR was the most significant interacting core target. (C–E) The crystal structure of DHA and EGFR and the molecular docking data were presented. The detailed information was presented in Table S1. (F–H) The targeting effect of DHA (60 μg/ml) on EGFR was analyzed by CETSA, wherein the expression of EGFR was detected by WB. The thermal solubility curve was displayed. (I) The expression of EGFR in DHA-treated lung cancer cells (60 μg/ml) was assayed by WB. (J) The mean gray of EGFR bands was analyzed and presented. Values were means ± SD (n = 5, **p < 0.01). (K) The EGF expression, which combined with EGFR, in the LLC was detected by the CO-IP.

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